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Contact
ERA CoBioTech Call Office State Research Agency (AEI) Manuel Sánchez-Blanco
+34 916038447 era-ib@aei.gob.es
Technical helpdesk for the submission system Project Management Juelich Dr. Petra E. Schulte, Irina Kobrin, Dr. Christian Breuer ptj-cobiotech@fz-juelich.de
glycosylation, small molecules, secretion, stability, water solubility
Topic A: Microbial communities (natural or synthetic), co-cultures and cascades of microorganisms for new products, value-added products and supply services as well as sustainable industrial processes.
We are offering a library of plant glycosyltransferases able to modify a range of small molecules including terpenoids, phenolics and alkaloids. Glucosylation by biotransformation has been shown for aliphatic alcohols, monoterpenoids, sesquiterpenoids, diterpenoids, phenolics, mycotoxins, etc. O-glycosylation (glycosides and glucose ester formation) and N-glycosylation has been demonstrated.
Glycosides are less toxic than their aglycones and are actively transported from microbial cells. Thus, significantly increased titers can be expected. The aglycones can be obtained by treatment with glycosidases.
Glycosylation is a final step in plant secondary metabolism, increasing the water solubilityand stability of the aglycones.
The Technische Universität München (TUM) has earned a high international reputation that is apparent from research collaborations with more than 140 partner Universities, and its involvement in more than 100 EU projects, 500 projects financed by the German Federal Ministry of Science and in 20 special research programs financed by the German Research Society (DFG). TUM pursues a sustainable strategy of promoting high quality research and supports scientists at each stage of career development.
The TUM group ‘Biotechnology of Natural Products’ works within the department Food and Nutrition at the Center of Life and Food Sciences, Land Use and Environment in Weihenstephan, Freising which pertains to TUM. The campus in Weihenstephan hosts groups working in plant genetics, plant metabolism, nutrition, food chemistry, food technology, crop protection, ecology and agricultural systems. The TUM group ‘Biotechnology of Natural Products’ has concentrated on investigating plant physiology using chemical-analytical, biochemical and molecular biological methods. The focus is on the biotechnological use of plant glycosyltransferases.